I heard back from my brother, with some details about ramifications of this that I had not considered. (And I feel fairly certain that Trump and Musk haven't, either, since it didn't even occur to them that firing the nuclear weapons workers would be a mistake.)
Not all research is funded by the government, but for those with projects that are, he says they've already received stop-work orders. He says that probably Boston will no longer be the biomedical research capital of the world. Foreign student enrollment will fall off in the US by a lot this year, and foreign students pay full tuition, generally, so that will be a loss. He said Chinese students, in particular, often stay to do research, and eventually become citizens, which they now won't. When the money gets a lot smaller, the best scientists will go abroad, (Europe, UK, Asia, Australia, Canada,) but the money is less than what it was here. In any case, it adds up to a brain drain for the US that will last for decades. These cuts, along with recession and the effect of tariffs, plus the fact that Trump wants to strip Harvard of its non-profit status. So, that's Boston devastated. And good jobs for scientists across the country reduced, unless the administration plans to move that money to red states, and not just save it for taxes cuts for the wealthiest, though I suspect the latter.
He said Harvard will spend a lot of money in lawsuits, many of which they'll win, but who knows what winning a lawsuit against the government even means anymore, in today's America.
In addition, tourism has dried up badly to the US. Canadians are pretty much not coming at all, nor Europeans. Something like $20 Bn in losses coming up is the Bloomberg estimate.